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Article

Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer.

International journal of clinical oncology - 1 Dec 2013

Nakanishi Ryota, Harada Jun, Tuul Munkhbold, Zhao Yan, Ando Koji, Saeki Hiroshi, Oki Eiji, Ohga Takefumi, Kitao Hiroyuki, Kakeji Yoshihiro, Maehara Yoshihiko

Abstract excerpt

BACKGROUND: Mutations of the KRAS or BRAF genes are now recognized as prognostic markers for colorectal cancer (CRC). They are also important predictive markers for resistance to the monoclonal antibodies that target the epidermal growth factor receptor. METHODS: In this retrospective study, KRAS and BRAF mutations were analyzed using a direct sequence method in 254 Japanese CRC patients, and the associations...

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Source

Identifiers

PMID: 23188063
DOI: 10.1007/s10147-012-0501-x

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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