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Article

Lineage-specific growth inhibition of NK cell lines by FOXO3 in association with Akt activation status.

Experimental hematology - 1 Dec 2012

Karube Kennosuke, Tsuzuki Shinobu, Yoshida Noriaki, Arita Kotaro, Liu Fang, Kondo Eisaku, Ko Young-Hyeh, Ohshima Koichi, Nakamura Shigeo, Kinoshita Tomohiro, Seto Masao

Abstract excerpt

FOXO3 and PRDM1 are located on 6q21, one of the most frequently deleted regions among natural killer (NK) cell neoplasms. We previously demonstrated that forced expression of each gene suppresses the proliferation of NK cell lines with the 6q deletion. In this study, the forced expression of FOXO3 or PRDM1 was performed in various cell lines to clarify these suppressive effects. Forced expression of PRDM1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O3

Share to Forkhead Transcription Factors

Share to Killer Cells, Natural

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Share to Positive Regulatory Domain I-Binding Factor 1

Share to Proto-Oncogene Proteins c-akt

Source

Identifiers

PMID: 22922206
DOI: 10.1016/j.exphem.2012.08.005

Genes

FOXO3
PRDM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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