Article
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 1999
Biggs W H, Meisenhelder J, Hunter T, Cavenee W K, Arden K C
Abstract excerpt
Although genetic analysis has demonstrated that members of the winged helix, or forkhead, family of transcription factors play pivotal roles in the regulation of cellular differentiation and proliferation, both during development and in the adult, little is known of the mechanisms underlying their regulation. Here we show that the activation of phosphatidylinositol 3 (PI3) kinase by extracellular growth factors...
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