The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis.

doi:10.1093/eurheartj/ehx624

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Article

The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis.

European heart journal - 7 Mar 2018

Loebel Madlen, Holzhauser Luise, Hartwig Jelka A, Shukla Praphulla C, Savvatis Konstantinos, Jenke Alexander, Gast Martina, Escher Felicitas, Becker Sonya C, Bauer Sandra, Stroux Andrea, Beling Antje, Kespohl Meike, Pinkert Sandra, Fechner Henry, Kuehl Uwe, Lassner Dirk, Poller Wolfgang, Schultheiss Heinz-Peter, Zeller Tanja, Blankenberg Stefan, Papageorgiou Anna-Pia, Heymans Stephane, Landmesser Ulf, Scheibenbogen Carmen, Skurk Carsten

Abstract excerpt

Aims: Foxo3 is a transcription factor involved in cell metabolism, survival, and inflammatory disease. However, mechanistic insight in Foxo3 effects is still limited. Here, we investigated the role of Foxo3 on natural killer (NK) cell responses and its effects in viral myocarditis. Methods and results: Effects of Foxo3 on viral load and immune responses were investigated in a model of coxsackie virus B3...

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Identifiers

PMID: 29136142
DOI: 10.1093/eurheartj/ehx624

Genes

FOXO3

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