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Article

Role of HLA-G 14bp deletion/insertion and +3142C>G polymorphisms in the production of sHLA-G molecules in relapsing-remitting multiple sclerosis.

Human immunology - 1 Nov 2012

Rizzo Roberta, Bortolotti Daria, Fredj Nadia Ben, Rotola Antonella, Cura Francesca, Castellazzi Massimiliano, Tamborino Carmine, Seraceni Silva, Baldi Eleonora, Melchiorri Loredana, Tola Maria Rosaria, Granieri Enrico, Baricordi Olavio R, Fainardi Enrico

Abstract excerpt

HLA-G is believed to act as an anti-inflammatory molecule in Multiple Sclerosis (MS). The 3' untranslated region of the HLA-G gene is characterized by two polymorphisms, DEL/INS14bp and +3142C>G, which control soluble HLA-G (sHLA-G) production. The influence of these two HLA-G variants on sHLA-G serum and cerebrospinal fluid (CSF) levels was investigated in 69 Relapsing-Remitting MS patients grouped in magnetic...

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PMID: 22922127
DOI: 10.1016/j.humimm.2012.08.005

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INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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