Article
HLA-G 14-bp polymorphism regulates the methotrexate response in rheumatoid arthritis.
Pharmacogenetics and genomics - 1 Sept 2006
Rizzo Roberta, Rubini Michele, Govoni Marcello, Padovan Melissa, Melchiorri Loredana, Stignani Marina, Carturan Sabrina, Ferretti Stefano, Trotta Francesco, Baricordi Olavio R
Abstract excerpt
OBJECTIVE: Methotrexate (MTX) represents the antirheumatic drug mainly used in rheumatoid arthritis (RA). HLA-G antigens are inducible nonclassical major histocompatibility complex class Ib molecules important for maintaining anti-inflammatory conditions. The HLA-G gene is characterized by a dele...
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