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Article

Thyroid hormone receptor beta mutations in the 'hot-spot region' are rare events in thyroid carcinomas.

The Journal of endocrinology - 1 Jan 2007

Rocha Ana Sofia, Marques Ricardo, Bento Inês, Soares Ricardo, Magalhães João, de Castro Inês Vieira, Soares Paula

Abstract excerpt

Thyroid cancer constitutes the most frequent endocrine neoplasia. Targeted expression of rearranged during transfection (RET)/papillary thyroid carcinoma (PTC) and V600E V-raf murine sarcoma viral oncogene homolog B1 (BRAF) to the thyroid glands of transgenic mice results in tumours similar to those of human PTC, providing evidence for the involvement of these oncogenes in PTC. Kato et al. developed a mouse model...

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Topics

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Share to Thyroid Hormone Receptors beta
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17210745
DOI: 10.1677/JOE-06-0009

Genes

THRB
BRAF
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thyroid hormone receptor beta mutations in the 'hot-spot region' are rare events in thyroid carcinomas.PMID 17210745Read ↗

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Thyroid hormone receptor beta (THRB) is a major target gene for microRNAs deregulated in papillary thyroid carcinoma (PTC).Semantic proximity Read ↗

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