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Article

Fine mapping for Weaver syndrome in Brown Swiss cattle and the identification of 41 concordant mutations across NRCAM, PNPLA8 and CTTNBP2.

PloS one - 1 Jan 2013

McClure Matthew, Kim Euisoo, Bickhart Derek, Null Daniel, Cooper Tabatha, Cole John, Wiggans George, Ajmone-Marsan Paolo, Colli Licia, Santus Enrico, Liu George E, Schroeder Steve, Matukumalli Lakshmi, Van Tassell Curt, Sonstegard Tad

Abstract excerpt

Bovine Progressive Degenerative Myeloencephalopathy (Weaver Syndrome) is a recessive neurological disease that has been observed in the Brown Swiss cattle breed since the 1970's in North America and Europe. Bilateral hind leg weakness and ataxia appear in afflicted animals at 6 to 18 months of age, and slowly progresses to total loss of hind limb control by 3 to 4 years of age. While Weaver has previously been...

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Source

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Identifiers

PMID: 23527149
DOI: 10.1371/journal.pone.0059251
PMCID: PMC3603989

Genes

CTTNBP2
NRCAM
PNPLA8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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