Article
Combined species identification, genotyping, and drug resistance detection of Mycobacterium tuberculosis cultures by MLPA on a bead-based array.
PloS one - 1 Jan 2012
Bergval Indra, Sengstake Sarah, Brankova Nadia, Levterova Viktoria, Abadía Edgar, Tadumaze Nino, Bablishvili Nino, Akhalaia Maka, Tuin Kiki, Schuitema Anja, Panaiotov Stefan, Bachiyska Elizabeta, Kantardjiev Todor, de Zwaan Rina, Schürch Anita, van Soolingen Dick, van 't Hoog Anja, Cobelens Frank, Aspindzelashvili Rusudan, Sola Christophe, Klatser Paul, Anthony Richard
Abstract excerpt
The population structure of Mycobacterium tuberculosis is typically clonal therefore genotypic lineages can be unequivocally identified by characteristic markers such as mutations or genomic deletions. In addition, drug resistance is mainly mediated by mutations. These issues make multiplexed detection of selected mutations potentially a very powerful tool to characterise Mycobacterium tuberculosis. We used...
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