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Identification of a Mycobacterium tuberculosis-specific gene marker for diagnosis of tuberculosis using semi-nested melt-MAMA qPCR (lprM-MAMA).

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2020

Chin Kai Ling, Sarmiento Maria E, Mustapha Zainal Arifin, Jani Jaeyres, Jamal Norfazirah Binti, Stanis Cheronie Shely, Acosta Armando

Abstract excerpt

Tuberculosis (TB) is the deadliest of infectious diseases. TB diagnosis, based on sputum microscopy, culture, and nucleic acid amplification tests (NAATs) to identify its main causative agent, Mycobacterium tuberculosis (MTB), remains challenging. The current available NAATs, endorsed by World Health Organization (WHO), can differentiate MTB from some MTB complex (MTBC) members. Using bioinformatics, we...

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PMID: 33099253
DOI: 10.1016/j.tube.2020.102003

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