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Article

Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors.

PloS one - 1 Jan 2012

Crisan Anamaria, Goya Rodrigo, Ha Gavin, Ding Jiarui, Prentice Leah M, Oloumi Arusha, Senz Janine, Zeng Thomas, Tse Kane, Delaney Allen, Marra Marco A, Huntsman David G, Hirst Martin, Aparicio Sam, Shah Sohrab

Abstract excerpt

Next generation sequencing has now enabled a cost-effective enumeration of the full mutational complement of a tumor genome-in particular single nucleotide variants (SNVs). Most current computational and statistical models for analyzing next generation sequencing data, however, do not account for...

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PMID: 22916110
DOI: 10.1371/journal.pone.0041551
PMCID: PMC3420914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22916110-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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