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Analytical characterization of host‐cell‐protein‐rich aggregates in monoclonal antibody solutions

5 Apr 2023

Abstract excerpt

Host-cell proteins (HCPs) and high molecular weight (HMW) species have historically been treated as independent classes of impurities in the downstream processing of monoclonal antibodies (mAbs), but recent indications suggest that they may be partially linked. We have explored this connection with a shotgun proteomic analysis of HMW impurities that were isolated from harvest cell culture fluid (HCCF) and protein...

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PMID: 37020359
DOI: 10.1002/btpr.3343

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