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Article

BRAG about (s)lots.

The Journal of cell biology - 4 Dec 2023

Brown Joshua C, Hell Johannes W, Gerges Nashaat Z

Abstract excerpt

Mutations in IQSEC2/BRAG1 cause intellectual dysfunction by impairing ARF-GEF activity and long-term depression. In this issue, Bai et al. (https://doi.org/10.1083/jcb.202307117) discover how constitutive ARF-GEF activity is regulated by a closed conformation which opens in the presence of Ca2+. Two known pathogenic mutations cause "leaky" autoinhibition with reduced synaptic dynamic range and impaired cognitive...

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Identifiers

PMID: 37938213
DOI: 10.1083/jcb.202310023
PMCID: PMC10631466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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