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Article

Ca2+-induced release of IQSEC2/BRAG1 autoinhibition under physiological and pathological conditions.

The Journal of cell biology - 4 Dec 2023

Bai Guanhua, Li Hao, Qin Pengwei, Guo Yiqing, Yang Wanfa, Lian Yinmiao, Ye Fei, Chen Jianxin, Wu Meiling, Huang Ruifeng, Li Jinsong, Lu Youming, Zhang Mingjie

Abstract excerpt

IQSEC2 (aka BRAG1) is a guanine nucleotide exchange factor (GEF) highly enriched in synapses. As a top neurodevelopmental disorder risk gene, numerous mutations are identified in Iqsec2 in patients with intellectual disabilities accompanied by other developmental, neurological, and psychiatric symptoms, though with poorly understood underlying molecular mechanisms. The atomic structures of IQSECs, together with...

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Identifiers

PMID: 37787765
DOI: 10.1083/jcb.202307117
PMCID: PMC10548395

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