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Article

Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.

PloS one - 1 Jan 2012

Gerecke Kim M, Jiao Yun, Pagala Viswajeeth, Smeyne Richard J

Abstract excerpt

Exercise has been demonstrated to potently protect substantia nigra pars compacta (SN) dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. One mechanism proposed to account for this neuroprotection is the upregulation of neurotrophic factors. Several neurotrophic factors, including Brain Derived Neurotrophic Factor (BDNF), have been shown to upregulate in response...

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Source

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Identifiers

PMID: 22912838
DOI: 10.1371/journal.pone.0043250
PMCID: PMC3422268

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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