Article
Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.
BMC cancer - 2 Aug 2010
Rocquain Julien, Carbuccia Nadine, Trouplin Virginie, Raynaud Stéphane, Murati Anne, Nezri Meyer, Tadrist Zoulika, Olschwang Sylviane, Vey Norbert, Birnbaum Daniel, Gelsi-Boyer Véronique, Mozziconacci Marie-Joelle
Abstract excerpt
BACKGROUND: Gene mutation is an important mechanism of myeloid leukemogenesis. However, the number and combination of gene mutated in myeloid malignancies is still a matter of investigation. METHODS: We searched for mutations in the ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in 65 myelodysplastic syndromes (MDSs) and 64 acute myeloid leukemias (AMLs) without balanced...
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