Article
Melanoma-patient-derived xenograft multi-omics resource melPDomiX maps gain- and loss-of-function alterations.
Cell reports - 23 Jun 2026
Tsingas Konstantinos, Thomas Monzy, Reale McKenna, Xiao Min, Wickramasinghe Jayamanna, Chen Yeqing, Duong Bryant, Lucas Anastasia, Thacker Gatha, Li Haiyin, Mou Haiwei, Ramirez-Salazar Eric, Elbasir Abdurrahman, Villanueva Jessie, Xu Xiaowei, Flowers Ahron, Karakousis Giorgos C, Miura John T, Mitchell Tara C, Amaravadi Ravi K, Schuchter Lynn M, Liu Shujing, Long Qi, Hoon Dave S B, Ramos Romela I, Catbagan Jose J, Bustos Matias A, Gershenwald Jeffrey E, Simon Julie M, Wargo Jennifer A, Davies Michael A, Lu Yiling, Mills Gordon B, Cohen Sonia, Lawless Aleigha, Sharova Tatyana, Frederick Dennie T, Flaherty Keith T, Hacohen Nir, Boland Genevieve M, Auslander Noam, Herlyn Meenhard
Abstract excerpt
Melanoma is a common and aggressive cancer, with rising incidence in most developed countries. Major discoveries in melanoma biology have been rapidly translated, allowing cures for patients in late-stage disease. Despite these advances, many tumors remain refractory, in part due to an incomplete understanding of the genes and pathways gained or lost during melanoma tumorigenesis. To address this gap and provide...
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