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Article

Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport.

The Journal of clinical investigation - 1 Jan 2004

Ferreirinha Fatima, Quattrini Angelo, Pirozzi Marinella, Valsecchi Valentina, Dina Giorgia, Broccoli Vania, Auricchio Alberto, Piemonte Fiorella, Tozzi Giulia, Gaeta Laura, Casari Giorgio, Ballabio Andrea, Rugarli Elena I

Abstract excerpt

In several neurodegenerative diseases, axonal degeneration occurs before neuronal death and contributes significantly to patients' disability. Hereditary spastic paraplegia (HSP) is a genetically heterogeneous condition characterized by selective degeneration of axons of the corticospinal tracts and fasciculus gracilis. HSP may therefore be considered an exemplary disease to study the local programs mediating...

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Share to ATPases Associated with Diverse Cellular Activities
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Metalloendopeptidases

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Share to Spastic Paraplegia, Hereditary

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Source

Open in PubMed Open full text

Identifiers

PMID: 14722615
DOI: 10.1172/JCI20138
PMCID: PMC311437

Genes

SPG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport.PMID 14722615Read ↗

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