Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival.

Brain research bulletin - 1 Jan 2013

Lopes da Fonseca Tomás, Correia Ana, Hasselaar Wiebren, van der Linde Herma C, Willemsen Rob, Outeiro Tiago Fleming

Abstract excerpt

ATP13A2 is a lysosome-specific transmembrane ATPase protein of unknown function. This protein was initially linked to Kufor-Rakeb syndrome where it is absent or mutated. More recently, point mutations in ATP13A2 were linked to familial cases of Parkinson's disease. Zebrafish is commonly used as a vertebrate model for the study of different neurodegenerative diseases and has homologues of several Parkinson's...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Nonmammalian
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Locomotion

Share to Morpholinos

Share to Proton-Translocating ATPases

Share to Sequence Homology

Share to Zebrafish

Share to Zebrafish Proteins

Source

Identifiers

PMID: 23123961
DOI: 10.1016/j.brainresbull.2012.09.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival.PMID 23123961Read ↗

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons.Semantic proximity Read ↗

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicitySemantic proximity Read ↗

Parkinson disease related ATP13A2 evolved early in animal evolutionSemantic proximity Read ↗

The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms.Semantic proximity Read ↗

Mutations in the ATP13A2 gene and Parkinsonism: a preliminary review.Semantic proximity Read ↗

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase.Semantic proximity Read ↗

The Roles of ATP13A2 Gene Mutations Leading to Abnormal Aggregation of α-Synuclein in Parkinson’s DiseaseSemantic proximity Read ↗

The Downregulation of c19orf12 Negatively Affects Neuronal and Musculature Development in Zebrafish EmbryosSemantic proximity Read ↗

Zebrafish as a novel model to assess Na+/K(+)-ATPase-related neurological disorders.Semantic proximity Read ↗

Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism.Semantic proximity Read ↗

Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans.Semantic proximity Read ↗

Adult-Onset Deletion of <i>ATP13A2</i> in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal AbnormalitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.