Article
The elongation rate of RNA polymerase II in zebrafish and its significance in the somite segmentation clock.
Development (Cambridge, England) - 15 Jan 2013
Hanisch Anja, Holder Maxine V, Choorapoikayil Suma, Gajewski Martin, Özbudak Ertugrul M, Lewis Julian
Abstract excerpt
A gene expression oscillator called the segmentation clock controls somite segmentation in the vertebrate embryo. In zebrafish, the oscillatory transcriptional repressor genes her1 and her7 are crucial for genesis of the oscillations, which are thought to arise from negative autoregulation of these genes. The period of oscillation is predicted to depend on delays in the negative-feedback loop, including, most...
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