Article
Detection of phenotype modifier genes using two-locus linkage analysis in complex disorders such as major psychosis.
Human heredity - 1 Jan 2012
Bureau Alexandre, Croteau Jordie, Mérette Chantal, Fournier Alain, Chagnon Yvon C, Roy Marc-André, Maziade Michel
Abstract excerpt
OBJECTIVE: To increase power to detect modifier loci conferring susceptibility to specific phenotypes such as disease diagnoses which are part of a broader disorder spectrum by jointly modeling a modifier and a broad susceptibility gene and to identify modifier loci conferring specific susceptibility to schizophrenia (SZ) or to bipolar disorder (BP) using the approach. METHODS: We implemented a two-locus linkage...
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