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Article

Carbohydrate- and conformation-dependent cargo capture for ER-exit.

Molecular biology of the cell - 1 Mar 2005

Appenzeller-Herzog Christian, Nyfeler Beat, Burkhard Peter, Santamaria Inigo, Lopez-Otin Carlos, Hauri Hans-Peter

Abstract excerpt

Some secretory proteins leave the endoplasmic reticulum (ER) by a receptor-mediated cargo capture mechanism, but the signals required for the cargo-receptor interaction are largely unknown. Here, we describe a novel targeting motif that is composed of a high-mannose type oligosaccharide intimately associated with a surface-exposed peptide beta-hairpin loop. The motif accounts for lectin ERGIC-53-assisted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15635097
DOI: 10.1091/mbc.e04-08-0708
PMCID: PMC551490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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