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Article

The relationship between risk-taking propensity and the COMT Val(158)Met polymorphism among early adolescents as a function of sex.

Journal of psychiatric research - 1 Jul 2012

Amstadter Ananda B, Macpherson Laura, Wang Frances, Banducci Anne N, Reynolds Elizabeth K, Potenza Marc N, Gelernter Joel, Lejuez C W

Abstract excerpt

Although adolescents frequently engage in a variety of risky behaviors, much remains unknown about the specific etiologies of such tendencies. Candidate genetic variants, such as the COMT Val(158)Met polymorphism, may be related to risk-taking propensity, particularly as this variant is linked to functional enzymatic differences influencing dopamine function in regions including the prefrontal cortex. The present...

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Source

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Identifiers

PMID: 22575334
DOI: 10.1016/j.jpsychires.2012.04.010
PMCID: PMC3687344

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The relationship between risk-taking propensity and the COMT Val(158)Met polymorphism among early adolescents as a function of sex.PMID 22575334Read ↗

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