Article
Systemic PPARγ deletion impairs circadian rhythms of behavior and metabolism.
PloS one - 1 Jan 2012
Yang Guangrui, Jia Zhanjun, Aoyagi Toshinori, McClain Donald, Mortensen Richard M, Yang Tianxin
Abstract excerpt
Compelling evidence from both human and animal studies suggests a physiological link between the circadian rhythm and metabolism but the underlying mechanism is still incompletely understood. We examined the role of PPARγ, a key regulator of energy metabolism, in the control of physiological and behavioral rhythms by analyzing two strains of whole-body PPARγ null mouse models. Systemic inactivation of PPARγ was...
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