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Article

Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development.

Endocrinology - 1 Nov 2016

Stump Madeliene, Guo Deng-Fu, Lu Ko-Ting, Mukohda Masashi, Cassell Martin D, Norris Andrew W, Rahmouni Kamal, Sigmund Curt D

Abstract excerpt

Peroxisome proliferator activated receptor (PPARγ) is a nuclear receptor transcription factor that regulates adipogenesis and energy homeostasis. Recent studies suggest PPARγ may mediate some of its metabolic effects through actions in the brain. We used a Cre-recombinase-dependent (using NestinCre) conditionally activatable transgene expressing either wild-type (WT) or dominant-negative (P467L) PPARγ to examine...

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Identifiers

PMID: 27575030
DOI: 10.1210/en.2016-1524
PMCID: PMC5086539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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