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Article

Discordant anatomical, electrophysiological, and visual behavioral profiles of retinal degeneration in rat models of retinal degenerative disease.

Investigative ophthalmology & visual science - 14 Sept 2012

McGill Trevor J, Prusky Glen T, Douglas Robert M, Yasumura Douglas, Matthes Michael T, Lowe Robert J, Duncan Jacque L, Yang Haidong, Ahern Kelly, Daniello Kate M, Silver Byron, LaVail Matthew M

Abstract excerpt

PURPOSE: To assess structural, functional, and visual behavioral relationships in mutant rhodopsin transgenic (Tg) rats and to determine whether early optokinetic tracking (OKT) visual experience, known to permanently elevate visual thresholds in normal rats, can enhance vision in rats with photoreceptor degeneration. METHODS: Eight lines of pigmented Tg rats and RCS rats were used in this study. OKT thresholds...

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Identifiers

PMID: 22899760
DOI: 10.1167/iovs.12-9569
PMCID: PMC3444210

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ERG

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