Inner retina remodeling in a mouse model of stargardt-like macular dystrophy (STGD3).

doi:10.1167/iovs.09-4718

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Article

Inner retina remodeling in a mouse model of stargardt-like macular dystrophy (STGD3).

Investigative ophthalmology & visual science - 1 Apr 2010

Kuny Sharee, Gaillard Frédéric, Mema Silvina C, Freund Paul R, Zhang Kang, Macdonald Ian M, Sparrow Janet R, Sauvé Yves

Abstract excerpt

Purpose. To investigate the impact of progressive age-related photoreceptor degeneration on retinal integrity in Stargardt-like macular dystrophy (STGD3). Methods. The structural design of the inner retina of the ELOVL4 transgenic mouse model of STGD3 was compared with that of age-matched littermate wild-type (WT) mice from 1 to 24 months of age by using immunohistofluorescence and confocal microscopy and by...

Topics

Aging
Animals
Biomarkers
Carrier Proteins
Disease Models, Animal
Electroretinography
Eye Proteins
Female
Fluorescent Antibody Technique, Indirect
Genotype
Macular Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Membrane Proteins

Mice

Mice, Inbred C57BL

Mice, Transgenic

Microscopy, Confocal

Photoreceptor Cells, Vertebrate

Source

Open in PubMed Open full text

Identifiers

PMID: 19933199
DOI: 10.1167/iovs.09-4718
PMCID: PMC2868397

Genes

ELOVL4
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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