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Article

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa.

Investigative ophthalmology & visual science - 1 Jan 2017

Sudharsan Raghavi, Simone Kristina M, Anderson Nathan P, Aguirre Gustavo D, Beltran William A

Abstract excerpt

Purpose: To characterize a light damage paradigm and establish structural and immunocytochemical measures of acute and protracted light-induced retinal degeneration in the rhodopsin (RHO) T4R dog model of RHO-autosomal dominant retinitis pigmentosa (ADRP). Methods: Retinal light damage was induced in mutant dogs with a 1-minute exposure to various light intensities (0.1-1.0 mW/cm2) delivered with a Ganzfeld...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28114588
DOI: 10.1167/iovs.16-20749
PMCID: PMC5464465

Genes

RHO
RPE

Variants

Provenance

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