Article
Biphasic photoreceptor degeneration induced by light in a T17M rhodopsin mouse model of cone bystander damage.
Investigative ophthalmology & visual science - 1 Jun 2009
Krebs Mark P, White D Alan, Kaushal Shalesh
Abstract excerpt
PURPOSE: To evaluate light-induced retinal damage in transgenic T17M rhodopsin mice as a novel model for bystander cone damage during retinal degeneration. METHODS: Mouse eyes were exposed to bright white light (15,000 lux, 2.5 minutes). After exposure, electroretinography was performed on mice dark adapted for 12 or more hours at 0 to 5 days to test photoreceptor response or for 0 to 12 hours to test response...
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