Article
Highly sensitive detection of EGFR T790M mutation using colony hybridization predicts favorable prognosis of patients with lung cancer harboring activating EGFR mutation.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2012
Fujita Yoshihiko, Suda Kenichi, Kimura Hideharu, Matsumoto Kazuko, Arao Tokuzo, Nagai Tomoyuki, Saijo Nagahiro, Yatabe Yasushi, Mitsudomi Tetsuya, Nishio Kazuto
Abstract excerpt
INTRODUCTION: Approximately 50% of lung cancer patients with epidermal growth factor receptor (EGFR)-mutations (deletion in exon 19 or L858R) who develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) reportedly carry a secondary EGFR T790M mutation. This mutation has been suggeste...
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