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Most T790M mutations are present on the same EGFR allele as activating mutations in patients with non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2017

Hidaka Noriko, Iwama Eiji, Kubo Naoki, Harada Taishi, Miyawaki Kohta, Tanaka Kentaro, Okamoto Isamu, Baba Eishi, Akashi Koichi, Sasaki Hiroyuki, Nakanishi Yoichi

Abstract excerpt

OBJECTIVES: The T790M and C797S mutations of the epidermal growth factor receptor gene (EGFR) confer resistance to first- and third-generation EGFR tyrosine kinase inhibitors (TKIs), respectively, in patients with non-small cell lung cancer (NSCLC) harboring activating mutations of EGFR. C797S has been identified in cis or in trans with T790M in tumor specimens from patients who experienced treatment failure with...

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Identifiers

PMID: 28625653
DOI: 10.1016/j.lungcan.2017.02.019

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EGFR

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