The application of real-time PCR technique to detect rare cell clones with primary T790M Substitution of EGFR gene in metastases of non-small cell lung cancer to central nervous system in chemotherapy naive patients.

doi:10.1007/s12253-014-9778-6

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The application of real-time PCR technique to detect rare cell clones with primary T790M Substitution of EGFR gene in metastases of non-small cell lung cancer to central nervous system in chemotherapy naive patients.

Pathology oncology research : POR - 1 Oct 2014

Powrózek Tomasz, Krawczyk Paweł, Jarosz Bożena, Mlak Radosław, Wojas-Krawczyk Kamila, Sawicki Marek, Stencel Dariusz, Trojanowski Tomasz, Milanowski Janusz

Abstract excerpt

The time-limited efficacy of reversible EGFR-TKIs in patients with advanced non-small cell lung cancer (NSCLC) with EGFR gene activating mutations is associated with development of treatment resistance after some period of therapy. This resistance predominantly results from secondary mutations located in EGFR gene, especially T790M substitution. There is limited information available concerning the prevalence of...

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The application of real-time PCR technique to detect rare cell clones with primary T790M Substitution of EGFR gene in metastases of non-small cell lung cancer to central nervous system in chemotherapy naive patients.

Abstract excerpt

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