The interplay of KRAS mutational status with tumor laterality in non-metastatic colorectal cancer: An international, multi-institutional study in patients with known KRAS, BRAF, and MSI status.

doi:10.1002/jso.26352

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Article

The interplay of KRAS mutational status with tumor laterality in non-metastatic colorectal cancer: An international, multi-institutional study in patients with known KRAS, BRAF, and MSI status.

Journal of surgical oncology - 1 Mar 2021

Kamphues Carsten, Kadowaki Shigenori, Amini Neda, van den Berg Inge, Wang Jaeyun, Andreatos Nikolaos, Sakamoto Yuki, Ogura Toshiro, Kakuta Miho, Pikouli Anastasia, Geka Despoina, Daitoku Nobuya, Theochari Maria, Buettner Stefan, Akiyama Takahiko, Antoniou Efstathios, Pikoulis Emmanouil, Theodoropoulos George, Imai Katsunori, Ijzermans Jan N M, Margonis Georgios A, Akagi Kiwamu, Kreis Martin E

Abstract excerpt

BACKGROUND: Although the prognostic relevance of KRAS status in metastatic colorectal cancer (CRC) depends on tumor laterality, this relationship is largely unknown in non-metastatic CRC. METHODS: Patients who underwent resection for non-metastatic CRC between 2000 and 2018 were identified from institutional databases at six academic tertiary centers in Europe and Japan. The prognostic relevance of KRAS status in...

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PMID: 33368279
DOI: 10.1002/jso.26352

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