Individualized significance of the -251 A/T single nucleotide polymorphism of interleukin-8 in severe infections.

doi:10.1007/s10096-015-2571-y

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Article

Individualized significance of the -251 A/T single nucleotide polymorphism of interleukin-8 in severe infections.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Apr 2016

Georgitsi M D, Vitoros V, Panou C, Tsangaris I, Aimoniotou E, Gatselis N K, Chasou E, Kouliatsis G, Leventogiannis K, Velissaris D, Belesiotou E, Dioritou-Aggaliadou O, Giannitsioti E, Netea M G, Giamarellos-Bourboulis E J, Giannikopoulos G, Alexiou Z, Voloudakis N, Koutsoukou A

Abstract excerpt

Based on the concept of the individualized nature of sepsis, we investigated the significance of the -251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary...

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PMID: 26768584
DOI: 10.1007/s10096-015-2571-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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