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Article

Analysis of HIV-1 envelope cytoplasmic tail effects on viral replication.

Virology - 1 Feb 2023

Alfadhli Ayna, Romanaggi CeAnn, Barklis Robin Lid, Barklis Eric

Abstract excerpt

Trimers of the HIV-1 envelope (Env) protein perform receptor binding and virus-cell fusion functions during the virus life cycle. The cytoplasmic tail (CT) of Env forms an unusual baseplate structure, and is palmitoylated, rich in arginines, carries trafficking motifs, binds cholesterol, and interacts with host proteins. To dissect CT activities, we examined a panel of Env variants, including CT truncations,...

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Identifiers

PMID: 36603533
DOI: 10.1016/j.virol.2022.12.017
PMCID: PMC10003682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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