Article
Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2012
Chen Xiqun, Tagliaferro Patricia, Kareva Tatyana, Yarygina Olga, Kholodilov Nikolai, Burke Robert E
Abstract excerpt
Mesencephalic dopamine neurons are central to many aspects of human cognition, motivational, and motor behavior, and they are uniquely vulnerable to degenerative neurologic disorders such as Parkinson's disease. There is growing evidence that in the mature brain these neurons not only remain responsive to neurotrophic support, but are dependent on it for viability and function. Little is known of the cellular...
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