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Glycogen Synthase Kinase-3β Regulates Equilibrium Between Neurogenesis and Gliogenesis in Rat Model of Parkinson's Disease: a Crosstalk with Wnt and Notch Signaling.

Molecular neurobiology - 1 Aug 2018

Singh Sonu, Mishra Akanksha, Bharti Sachi, Tiwari Virendra, Singh Jitendra, Parul, Shukla Shubha

Abstract excerpt

Neurogenesis involves generation of functional newborn neurons from neural stem cells (NSCs). Insufficient formation or accelerated degeneration of newborn neurons may contribute to the severity of motor/nonmotor symptoms of Parkinson's disease (PD). However, the functional role of adult neurogenesis in PD is yet not explored and whether glycogen synthase kinase-3β (GSK-3β) affects multiple steps of adult...

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PMID: 29327199
DOI: 10.1007/s12035-017-0860-4

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