Inhibition of Ubiquitin Specific Protease 1 Sensitizes Colorectal Cancer Cells to DNA-Damaging Chemotherapeutics

Abstract excerpt

Mutations and altered expression of DUBs have been found associated with many human diseases including cancers. In this study, USP1 expression was found significantly increased in some colorectal cancers (CRC). The elevated USP1 level was associated with short overall survival of patients and with advanced stages of cancers. MoreoverIn cultured CRC cells, knockdown of USP1 induced CRC cell growth arrest at G2/M...

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