Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

PloS one - 1 Jan 2012

De Saedeleer Christophe J, Copetti Tamara, Porporato Paolo E, Verrax Julien, Feron Olivier, Sonveaux Pierre

Abstract excerpt

Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoupling glycolysis from oxidative phosphorylation, directly participates in cancer aggressiveness, supporting both tumor progression and dissemination. The transcription factor hypoxia-inducible factor-1 (HIF-1) is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basigin
Share to Glycolysis
Share to Hypoxia-Inducible Factor 1, alpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor-Proline Dioxygenases

Share to Lactic Acid

Share to Monocarboxylic Acid Transporters

Share to Procollagen-Proline Dioxygenase

Share to Symporters

Source

Open in PubMed Open full text

Identifiers

PMID: 23082126
DOI: 10.1371/journal.pone.0046571
PMCID: PMC3474765

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.PMID 23082126Read ↗

Understanding the tumor metabolic phenotype in the genomic era.Semantic proximity Read ↗

Metabolic symbiosis in cancer: refocusing the Warburg lens.Semantic proximity Read ↗

The altered metabolism of tumors: HIF-1 and its role in the Warburg effect.Semantic proximity Read ↗

Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.Semantic proximity Read ↗

Warburg and pasteur phenotypes modulate cancer behavior and therapy.Semantic proximity Read ↗

Revisiting the biological role of the Warburg effect: Evolving perspectives on cancer metabolismSemantic proximity Read ↗

Drivers of the Warburg phenotype.Semantic proximity Read ↗

'The metabolism of tumours': 70 years later.Semantic proximity Read ↗

Warburg effect and lactylation in cancer: mechanisms for chemoresistanceSemantic proximity Read ↗

A gene for all seasons: The evolutionary consequences of HIF-1 in carcinogenesis, tumor growth and metastasisSemantic proximity Read ↗

Metabolic reprogramming and two-compartment tumor metabolismSemantic proximity Read ↗

Fatal Alliance of Hypoxia-/HIF-1α-Driven Microenvironmental Traits Promoting Cancer Progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.