Article
Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.
Diabetologia - 1 Nov 2012
Liu C-T, Ng M C Y, Rybin D, Adeyemo A, Bielinski S J, Boerwinkle E, Borecki I, Cade B, Chen Y D I, Djousse L, Fornage M, Goodarzi M O, Grant S F A, Guo X, Harris T, Kabagambe E, Kizer J R, Liu Y, Lunetta K L, Mukamal K, Nettleton J A, Pankow J S, Patel S R, Ramos E, Rasmussen-Torvik L, Rich S S, Rotimi C N, Sarpong D, Shriner D, Sims M, Zmuda J M, Redline S, Kao W H, Siscovick D, Florez J C, Rotter J I, Dupuis J, Wilson J G, Bowden D W, Meigs J B
Abstract excerpt
AIMS/HYPOTHESIS: Hyperglycaemia disproportionately affects African-Americans (AfAs). We tested the transferability of 18 single-nucleotide polymorphisms (SNPs) associated with glycaemic traits identified in European ancestry (EuA) populations in 5,984 non-diabetic AfAs. METHODS: We meta-analysed SNP associations with fasting glucose (FG) or insulin (FI) in AfAs from five cohorts in the Candidate Gene Association...
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