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Article

VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children.

Blood - 19 Jan 2012

Biss Tina T, Avery Peter J, Brandão Leonardo R, Chalmers Elizabeth A, Williams Michael D, Grainger John D, Leathart Julian B S, Hanley John P, Daly Ann K, Kamali Farhad

Abstract excerpt

Although genetic and environmental factors explain approximately half of the interindividual variability in warfarin dose requirement in adults, there is limited information available in children. In a cross-sectional study of anticoagulated children from 5 tertiary care centers, 120 children with a stable warfarin dose were genotyped for VKORC1 (-1639G > A; rs9923231), CYP2C9 (*2 and *3 alleles; rs1799853 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22010099
DOI: 10.1182/blood-2011-08-372722

Genes

VKORC1

Variants

rs9923231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children.PMID 22010099Read ↗

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