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Article

CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis.

The pharmacogenomics journal - 1 Apr 2020

Takeuchi Masanobu, Kobayashi Tohru, Biss Tina, Kamali Farhad, Vear Susan I, Ho Richard H, Bajolle Fanny, Loriot Marie-Anne, Shaw Kaitlyn, Carleton Bruce C, Hamberg Anna-Karin, Wadelius Mia, Hirono Keiichi, Taguchi Masato, Wakamiya Takuya, Yanagimachi Masakatsu, Hirai Keita, Itoh Kunihiko, Brandão Leonardo R, Ito Shinya

Abstract excerpt

Studies on the effect of cytochrome P450 2C9 (CYP2C9), vitamin K epoxide reductase complex subunit 1 (VKORC1), and cytochrome P450 4F2 (CYP4F2) polymorphisms on warfarin maintenance dose in children are conflicting. We conducted a systematic review and meta-analysis to evaluate the effect of these polymorphisms on warfarin maintenance dose in children. We searched relevant literature using the MEDLINE, EMBASE,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31673144
DOI: 10.1038/s41397-019-0117-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CYP2C9, VKORC1, and CYP4F2 polymorphisms and pediatric warfarin maintenance dose: a systematic review and meta-analysis.PMID 31673144Read ↗

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