Human alpha-actinin-3 genotype association with exercise-induced muscle damage and the repeated-bout effect.

doi:10.1139/h2012-087

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Article

Human alpha-actinin-3 genotype association with exercise-induced muscle damage and the repeated-bout effect.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme - 1 Dec 2012

Venckunas Tomas, Skurvydas Albertas, Brazaitis Marius, Kamandulis Sigitas, Snieckus Audrius, Moran Colin N

Abstract excerpt

Alpha-actinin-3 (ACTN3) is an integral part of the Z line of the sarcomere. The ACTN3 R577X (rs1815739) polymorphism determines the presence or absence of functional ACTN3, which may influence the extent of exercise-induced muscle damage. This study aimed to compare the impact of, and recovery from, muscle-damaging eccentric exercise on subjects with or without functional ACTN3. Seventeen young men (20-33 years...

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Identifiers

PMID: 22891846
DOI: 10.1139/h2012-087

Genes

ACTN3

Variants

rs1815739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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