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Article

Protective role of alpha-actinin-3 in the response to an acute eccentric exercise bout.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Aug 2010

Vincent Barbara, Windelinckx An, Nielens Henri, Ramaekers Monique, Van Leemputte Marc, Hespel Peter, Thomis Martine A

Abstract excerpt

The ACTN3 gene encodes for the alpha-actinin-3 protein, which has an important structural function in the Z line of the sarcomere in fast muscle fibers. A premature stop codon (R577X) polymorphism in the ACTN3 gene causes a complete loss of the protein in XX homozygotes. This study investigates a possible role for the alpha-actinin-3 protein in protecting the fast fiber from eccentric damage and studies repair...

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Source

Identifiers

PMID: 20507967
DOI: 10.1152/japplphysiol.01007.2009

Genes

CSRP3
ACTN3
RCAN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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