Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ACTN3 and MLCK genotype associations with exertional muscle damage.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Aug 2005

Clarkson Priscilla M, Hoffman Eric P, Zambraski Edward, Gordish-Dressman Heather, Kearns Amy, Hubal Monica, Harmon Brennan, Devaney Joseph M

Abstract excerpt

Strenuous exercise results in damage to skeletal muscle that is manifested in delayed muscle pain, prolonged strength loss, and increases in muscle proteins in the blood, especially creatine kinase (CK) and myoglobin (Mb). Some individuals experience profound changes in these variables in response to standard laboratory exercise or recreational activities. We proposed that variations in genes coding for two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actinin
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Peptides

Share to Phenotype

Share to Physical Endurance

Share to Physical Exertion

Share to Rhabdomyolysis

Source

Identifiers

PMID: 15817725
DOI: 10.1152/japplphysiol.00130.2005

Genes

ACTN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ACTN3 and MLCK genotype associations with exertional muscle damage.PMID 15817725Read ↗

Human alpha-actinin-3 genotype association with exercise-induced muscle damage and the repeated-bout effect.Semantic proximity Read ↗

Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing.Semantic proximity Read ↗

ACTN3 genotype influences exercise-induced muscle damage during a marathon competition.Semantic proximity Read ↗

ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women.Semantic proximity Read ↗

ACTN3 X-allele carriers had greater levels of muscle damage during a half-ironman.Semantic proximity Read ↗

Association of the ACTN3 Genotype with Muscle Function: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

The Effect of Heterozygosity for the ACTN3 Null Allele on Human Muscle Performance.Semantic proximity Read ↗

The ACTN3 genotype in soccer players in response to acute eccentric training.Semantic proximity Read ↗

IGF-II gene region polymorphisms related to exertional muscle damage.Semantic proximity Read ↗

Genetic polymorphisms associated with exertional rhabdomyolysis.Semantic proximity Read ↗

ACTN3 R577X Polymorphism Is Associated With the Incidence and Severity of Injuries in Professional Football Players.Semantic proximity Read ↗

Influence of Alpha-Actinin-3 R577X Polymorphism on Muscle Damage and the Inflammatory Response after an Acute Strength Training Session.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.