Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.

Abstract excerpt

Alpha-actinins are structural proteins of the Z-line. Human skeletal muscle expresses two alpha-actinin isoforms, alpha-actinin-2 and alpha-actinin-3, encoded by their respective genes ACTN2 and ACTN3. ACTN2 is expressed in all muscle fiber types, while only type II fibers, and particularly the type IIb fibers, express ACTN3. ACTN3 (R577X) polymorphism results in loss of alpha-actinin-3 and has been suggested to...

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• Actinin
• Gene Expression
• Muscle Fibers, Fast-Twitch
• Muscle Fibers, Skeletal
• Muscle Fibers, Slow-Twitch