Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IRF1 suppresses Ki-67 promoter activity through interfering with Sp1 activation.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Dec 2012

Chen Feifei, Song Jian, Di Jiehui, Zhang Qing, Tian Hui, Zheng Junnian

Abstract excerpt

Interferon regulatory factor 1 (IRF1) shows tumor-suppressor activity by suppressing proliferation of cancer cells. To exert its anti-proliferative effects, this factor must ultimately control transcription of several key genes that regulate cell cycle progression. Here, we showed that Ki-67 gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunoenzyme Techniques
Share to Interferon Regulatory Factor-1
Share to Ki-67 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Neoplasms

Share to Luciferases

Share to Real-Time Polymerase Chain Reaction

Share to Sp1 Transcription Factor

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 22890831
DOI: 10.1007/s13277-012-0483-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22890831-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IRF1 suppresses Ki-67 promoter activity through interfering with Sp1 activation.PMID 22890831Read ↗

The Tumor Suppressor Interferon Regulatory Factor 1 Interferes with SP1 Activation to Repress the Human CDK2 PromoterSemantic proximity Read ↗

Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling PathwaysSemantic proximity Read ↗

Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory FactorSemantic proximity Read ↗

The Sp1 family of transcription factors is involved in p27(Kip1)-mediated activation of myelin basic protein gene expression.Semantic proximity Read ↗

Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism.Semantic proximity Read ↗

Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells.Semantic proximity Read ↗

Sp1 is required for prolactin activation of the interferon regulatory factor-1 gene.Semantic proximity Read ↗

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).Semantic proximity Read ↗

Direct repression of the human IRF-3 promoter by E2F1.Semantic proximity Read ↗

IFN‐γ/IRF‐1‐induced p27<sup><i>kip1</i></sup> down‐regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancerSemantic proximity Read ↗

Mutant p27(Kip1) and its potential effect as hepatocellular gene therapy.Semantic proximity Read ↗

Dual regulation of ets-activated gene expression by SP1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.