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IFN‐γ/IRF‐1‐induced p27<sup><i>kip1</i></sup> down‐regulates telomerase activity and human telomerase reverse transcriptase expression in human cervical cancer

13 Jan 2005

Abstract excerpt

Telomerase activation is regulated by the expression of human telomerase reverse transcriptase (hTERT) and is a key step in the development of human cancers. Interferon-gamma (IFN-gamma) signaling induces growth arrest in many tumors through multiple regulatory mechanisms. The p27 tumor suppressor protein inhibits the formation of tumors through the induction of cell cycle arrest and/or apoptosis. We demonstrate...

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PMID: 15710386
DOI: 10.1016/j.febslet.2005.01.005

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