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Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor

15 Aug 2001

Abstract excerpt

The irreversible cell cycle arrest and apoptosis induced by p53 are part of the host surveillance mechanisms for viral infection and tumor induction. Kaposi's sarcoma-associated herpesvirus (KSHV), the most recently discovered human tumor virus, is associated with the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The K9 open reading frame of KSHV encodes a...

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PMID: 11462029
DOI: 10.1128/jvi.75.16.7572-7582.2001

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Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory FactorPMID 11462029Read ↗

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