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Article

Sp1 is required for prolactin activation of the interferon regulatory factor-1 gene.

Molecular and cellular endocrinology - 26 Nov 2001

Book McAlexander M, Yu-Lee L Y

Abstract excerpt

Transcription of the interferon regulatory factor-1 gene (IRF-1) is induced in a biphasic manner (G1 and G1/S phase) in Nb2 T cells in response to prolactin (PRL) stimulation. Signal transducer and activator of transcription 1 (Stat1) is required for PRL activation of the IRF-1 promoter. Mutation of a -200 bp Sp1 site in the IRF-1 promoter results in a loss of G1 but not G1/S IRF-1 transcriptional activity in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11694349
DOI: 10.1016/s0303-7207(01)00593-7

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Sp1 is required for prolactin activation of the interferon regulatory factor-1 gene.PMID 11694349Read ↗

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